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BCR/ABL1, t(9;22)

CPT 88271, 88275, 88274 (use multipliers as necessary)

Test Details

Cancer Type

Acute myelocytic leukemia (AML), Chronic myelogenous leukemia (CML), Hematologic malignancies

Technology Used

FISH

Turnaround Time

3-5 days

View Requisition Forms

Use

B-ALL (adult and pediatric), AML, CML

Special Instructions

If aspiration syringe requires internal pre-coating to prevent clotting, diluted sodium heparin (green-top) tube should be utilized. Do not send syringes. 2-3 mL aseptically aspirated in sodium heparin (green-top) tube. Cautionary Note: Lithium heparin also comes in green-top collection tubes. Do not collect in lithium heparin.

Methodology

Fluorescence in situ hybridization (FISH)

Specimen Requirements

Information on collection, storage, and volume

Specimen

Bone marrow aspirate (preferred); whole blood (acceptable for limited tests)

Volume

3 mL bone marrow; 10 mL blood (adult), 5 mL blood (pediatric); fixed-cell pellet

Storage Instructions

Refrigerate bone marrow and blood specimens

Causes for Rejection

Do not collect in lithium heparin.

Collection

Refrigerate specimen. Use cold pack for transport. Be sure cold pack is not in direct contact with specimen during transport. All specimens should be shipped to Labcorp Oncology on the day of collection. Delay in shipping may compromise cell viability and results. 

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