This latest molecular tumor board reviews a case of a 68 year-old female with metastatic lung adenocarcinoma with an EGFR L848R mutation. Frontline biomarker testing provided initial options for therapy, but at progression liquid biopsy testing was confounded by clonal hematopoiesis.
Recognizing and mitigating cancer treatment toxicities is an essential piece of a survivorship plan after curaing cancer. Our latest molecular tumor board discusses an important intersection of cardiology and oncology in breast cancer through a case of a 33-year-old female with locally advanced ER/PR-negative, HER2-positive breast cancer.
Circulating tumor DNA (ctDNA) can detect primary resistance to immunotherapy in patients with lung cancer. In the first stage of this phase 2 trial, we evaluated 50 patients with advanced non-small cell lung cancer who received standard of care pembrolizumab to determine ctDNA response and its concordance with imaging.