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ROS1 and RET Gene Rearrangements

CPT 88271; 88275

Test Details

Cancer Type

Lung, Non-small cell lung cancer

Technology Used

FISH

Turnaround Time

5-7 days
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Use

Confirmation/identification of cancer-related alterations in nonˆ’small-cell lung cancer

Test Includes

ROS1 and/or RET gene reararrangements by FISH

Methodology

FISH

Related Documents

NSCLC - ROS1 and RET Gene Rearrangements - October 2012

    References

    Takeuchi K, Soda M, Togashi Y, et al. RET, ROS1 and ALK fusions in lung cancer. Nat Med. 2012 Feb 12; 18(3):378-381.

    Specimen Requirements

    Information on collection, storage, and volume

    Specimen

    FNA; formalin-fixed paraffin-embedded blocks are acceptable

    Volume

    Five slides (4- to 5-micron thick sections)

    Container

    Formalin-fixed, paraffin-embedded (FFPE) tissue blocks or slides

    Storage Instructions

    Store specimens at room temperature

    Causes for Rejection

    Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; absence of tumor or quantity not sufficient for analysis

    Collection

    Tissue should be in formalin. If alternative fixative is used, it should be noted on the requisition. Send all slides within 6 weeks of cutting. Pre-cut slides from paraffin block in 5 micron sections and mounted on Poly-L-Lysine-coated or plus (+) slides Air dry. Do not oven dry.
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